Despite its uniform appearance, the cerebellar cortex is highly heterogeneous in terms of structure, genetics and physiology. Purkinje cells (PCs), the principal and sole output neurons of the cerebellar cortex, can be categorized into multiple populations that differentially express molecular markers and display distinctive physiological features. Such features include action potential rate, but also their propensity for synaptic and intrinsic plasticity. However, the precise molecular and genetic factors that correlate with the differential physiological properties of PCs remain elusive. In this (...) article, we provide a detailed overview of the cellular mechanisms that regulate PC activity and plasticity. We further perform a pathway analysis to highlight how molecular characteristics of specific PC populations may influence their physiology and plasticity mechanisms. (shrink)

Attentional bias has been suggested to contribute to the persistence of substance use behavior. However, the empirical evidence for its proposed role in addiction is inconsistent. This might be due to the inability of commonly used measures to differentiate between attentional engagement and attentional disengagement. Attesting to the importance of differentiating between both components of AB, a recent study using the odd-one-out task showed that substance use was differentially related to engagement and disengagement bias. However, the AB measures derived from (...) the OOOT showed insufficient reliability to be used as a solid measure of individual differences. Therefore, the current study aimed to improve the reliability of the AB measures derived from the OOOT by using more distinct contrast stimuli, adding practice trials, increasing the number of trials, and by having participants perform the task in an alcohol-relevant context. We contrasted the original OOOT with the adapted OOOT and assessed AB in low- and high-drinking individuals. Participants were 245 undergraduate students who typically tend to drink either low or high amounts of alcohol. In one condition, AB was measured with the original OOOT in a typical laboratory context, whereas in the other condition, AB was measured with the OOOT-adapt in a bar context. The OOOT-adapt showed superior internal consistency, especially for the high-drinking group. Further, specifically the OOOT-adapt differentiated between low- and high-drinking participants showing that high drinkers engaged faster with alcohol cues than did low drinkers. Thus, the OOOT-adapt was found to be a promising candidate to reliably index AB in the context of alcohol use. The OOOT-adapt further showed superior criterion validity as it could differentiate between low- and high-drinking individuals, thereby adding to the evidence that AB might be involved in substance use behavior. (shrink)

Alan C. LoveDarwinian calisthenicsAn athlete engages in calisthenics as part of basic training and as a preliminary to more advanced or intense activity. Whether it is stretching, lunges, crunches, or push-ups, routine calisthenics provide a baseline of strength and flexibility that prevent a variety of injuries that might otherwise be incurred. Peter Bowler has spent 40 years doing Darwinian calisthenics, researching and writing on the development of evolutionary ideas with special attention to Darwin and subsequent filiations among scientists exploring (...) evolution . Therefore, we would expect that when Bowler engages in a counterfactual history—imagining a world without Darwin—he is able to avoid historical injury and generate novel insights. My assessment is that the results are mixed. Before we can see why, it is necessary to walk briskly through the main contours of his argument.Bowler begins with an apologia for a counterfactual appr .. (shrink)

The view advanced by Madole & Harden falls back on the dogma of a gene as a DNA sequence that codes for a fixed product with an invariant function regardless of temporal and spatial contexts. This outdated perspective entrenches the metaphor of genes as static units of information and glosses over developmental complexities.

Peter J Arnold; Sport, Moral Education and the Development of Character, Journal of Philosophy of Education, Volume 18, Issue 2, 30 May 2006, Pages 275–281, htt.

This article outlines a training activity that can enable both business and governmental professionals to translate the principles in a code of ethics to a specific list of company-related behaviors ranging from highly ethical to highly unethical. It also explores how this list can become a concrete model to follow in making ethical decisions. The article begins with a discussion as to what will improve ethical decision making in business and government. This leads us to explore the factors that can (...) most easily lead to improvement, namely a comprehensive code of conduct and employee training. From there we look at the Critical Incident Technique as a training strategy that has the potential for identifying those behaviors that distinguish really outstanding behaviors from those that go by the book, and can be used to encourage more independent thinking and to set expectations for future decisions. If employees are given the skills and examples that will enable them to make better decisions, they can apply them to any situation. (shrink)

Perceptual entitlement and basic beliefs Content Type Journal Article DOI 10.1007/s11098-010-9603-3 Authors Peter J. Graham, University of California, 900 University Avenue, Riverside, CA USA Journal Philosophical Studies Online ISSN 1573-0883 Print ISSN 0031-8116.

Behaviour norms are considered for decision trees which allow both objective probabilities and uncertain states of the world with unknown probabilities. Terminal nodes have consequences in a given domain. Behaviour is required to be consistent in subtrees. Consequentialist behaviour, by definition, reveals a consequence choice function independent of the structure of the decision tree. It implies that behaviour reveals a revealed preference ordering satisfying both the independence axiom and a novel form of sure-thing principle. Continuous consequentialist behaviour must be expected (...) utility maximizing. Other plausible assumptions then imply additive utilities, subjective probabilities, and Bayes' rule. (shrink)

Acknowledgments 1. Culture Is Essential 2. Culture Exists 3. Culture Evolves 4. Culture Is an Adaptation 5. Culture Is Maladaptive 6. Culture and Genes Coevolve 7. Nothing about Culture Makes Sense except in the Light of Evolution.

As science learns more about how the brain works, and fails to work, the possibility for developing “cognition enhancers” becomes more plausible. And the demand for drugs that can help us think faster, remember more, and focus more keenly has already been demonstrated by the market success of drugs like Ritalin, which tames the attention span, and Prozac, which ups the competitive edge. The new drug Aricept, which improves memory, most likely will join them. Whether such drugs are good for (...) individuals, or for society, is an open question, one that demands far more public discussion. (shrink)

What is the best account of process reliabilism about epistemic justification, especially epistemic entitlement? I argue that entitlement consists in the normal functioning (proper operation) of the belief-forming process when the process has forming true beliefs reliably as an etiological function. Etiological functions involve consequence explanation: a belief-forming process has forming true beliefs reliably as a function just in case forming-true beliefs reliably partly explains the persistence of the process. This account paves the way for avoiding standard objections to process (...) reliabilism and situations epistemic entitlement within a normative framework of functions and functional norms. (shrink)

This paper argues that as a name for a speech act, epistemologists typically use ‘testimony’ in a specialist sense that is more or less synonymous with ‘assertion’, but as a name for a distinctive speech act type in ordinary English, ‘testimony’ names a unique confirmative speech act type. Hence, like any good English word, ‘testimony’ has more than one sense. The paper then addresses the use of ‘testimony’ in epistemology to denote a distinctive kind of evidence: testimonial evidence. Standing views (...) of a hearer’s testimonial evidence see it as partly supervening on a speaker’s assertion that P. The paper argues for a broader account that sees a hearer’s testimonial evidence as partly supervening instead on the hearer’s representation as of a speaker meaning that P. This broader account is the comprehension view of testimonial evidence. The upshot is that not all so-called “testimony-based beliefs” are caused by a speaker’s testimony. (shrink)

Much of what we believe we know, we know through the testimony of others. While there has been long-standing evidence that people are sensitive to the characteristics of the sources of testimony, for example in the context of persuasion, researchers have only recently begun to explore the wider implications of source reliability considerations for the nature of our beliefs. Likewise, much remains to be established concerning what factors influence source reliability. In this paper, we examine, both theoretically and empirically, the (...) implications of using message content as a cue to source reliability. We present a set of experiments examining the relationship between source information and message content in people's responses to simple communications. The results show that people spontaneously revise their beliefs in the reliability of the source on the basis of the expectedness of a source's claim and, conversely, adjust message impact by perceived reliability; hence source reliability and message content have a bi-directional relationship. The implications are discussed for a variety of psychological, philosophical and political issues such as belief polarization and dual-route models of persuasion. (shrink)

In A Professor's Duties, distinguished philosopher Peter J. Markie adds to the expanding discussion of the ethics of college teaching. Part One concentrates on the obligations of individual professors, primarily with regard to issues about what and how to teach. Part Two expands Professor Markie's views by providing a selection of the most significant previously published writings on the ethics of college teaching.

The essays in this volume, first published in 1986, examine the philosophical foundations of social choice theory. This field, a modern and sophisticated outgrowth of welfare economics, is best known for a series of impossibility theorems, of which the first and most crucial was proved by Kenneth Arrow in 1950. That has often been taken to show the impossibility of democracy as a procedure for making collective decisions. However, this interpretation is challenged by several of the contributors here. Other central (...) issues discussed in the volume include the possibility of making interpersonal comparisons of utility, the question of whether all preferences are equally to be valued, and the normative individualism underlying the theoretical tradition. Criticisms of social choice theory are advanced and suggestions for alternative approaches are developed. (shrink)

Putnam and Laudan separately argue that the falsity of past scientific theories gives us reason to doubt the truth of current theories. Their arguments have been highly influential, and have generated a significant literature over the past couple of decades. Most of this literature attempts to defend scientific realism by attacking the historical evidence on which the premises of the relevant argument are based. However, I argue that both Putnam's and Laudan's arguments are fallacious, and hence attacking their premises is (...) unnecessary. The paper concludes with a discussion of the further historical evidence that would be required if the pessimistic induction is to present a serious threat to scientific realism. (shrink)

The use of socially learned information (culture) is central to human adaptations. We investigate the hypothesis that the process of cultural evolution has played an active, leading role in the evolution of genes. Culture normally evolves more rapidly than genes, creating novel environments that expose genes to new selective pressures. Many human genes that have been shown to be under recent or current selection are changing as a result of new environments created by cultural innovations. Some changed in response to (...) the development of agricultural subsistence systems in the Early and Middle Holocene. Alleles coding for adaptations to diets rich in plant starch (e.g., amylase copy number) and to epidemic diseases evolved as human populations expanded (e.g., sickle cell and G6PD defi- ciency alleles that provide protection against malaria). Large-scale scans using patterns of linkage disequilibrium to detect recent selection suggest that many more genes evolved in response to agriculture. Genetic change in response to the novel social environment of contemporary modern societies is also likely to be occurring. The functional effects of most of the alleles under selection during the last 10,000 years are currently unknown. Also unknown is the role of paleoenvironmental change in regulating the tempo of hominin evolution. Although the full extent of culture-driven gene-culture coevolution is thus far unknown for the deeper history of the human lineage, theory and some evidence suggest that such effects were profound. Genomic methods promise to have a major impact on our understanding of gene-culture coevolution over the span of hominin evolutionary history. (shrink)

Ambitiously identifying fresh issues in the study of complex systems, Peter J. Taylor, in a model of interdisciplinary exploration, makes these concerns accessible to scholars in the fields of ecology, environmental science, and science studies. Unruly Complexity explores concepts used to deal with complexity in three realms: ecology and socio-environmental change; the collective constitution of knowledge; and the interpretations of science as they influence subsequent research. For each realm Taylor shows that unruly complexity-situations that lack definite boundaries, where what (...) goes on "outside" continually restructures what is "inside," and where diverse processes come together to produce change-should not be suppressed by partitioning complexity into well-bounded systems that can be studied or managed from an outside vantage point. Using case studies from Australia, North America, and Africa, he encourages readers to be troubled by conventional boundaries-especially between science and the interpretation of science-and to reflect more self-consciously on the conceptual and practical choices researchers make. (shrink)

Historically, the hypothesis driving emotion research has been that emotion’s data-base—in language, physiology, and behavior— is organized around specific mental states, as reflected in evaluative language. It is suggested that this approach has not greatly advanced a natural science of emotion and that the developing motivational model of emotion defines a better path: emotion is an evolved trait founded on motivational neural circuitry shared by mammalian species, primitively prompting heightened perceptual processing and reflex mobilization for action to appetitive or threatening (...) survival cues. As the field moves forward with increasingly sophisticated measurement technology and assessing more complex affective functioning, scientific understanding of human emotion will proceed best within the framework of this mammalian brain model. (shrink)

The work encompasses analysis of philosophers and writers from ancient times through to the present day and examines such episodes as the Oklahoma City Federal ...

Propositionalism explains the nature of knowledge-how as follows: P: To know how to ϕ is to stand in a special propositional attitude relation to propositions about how to ϕ. To know how to ride a bike is to have the required propositional attitude to propositions about how to do so. Dispositionalism offers an alternative view.D: To know how to ϕ is to stand in a behavioral-dispositional relation, a being-able-to relation, to ϕ-ing. To know how to ride a bike is to (...) have an ability to do so in the form of a complex disposition to behave in ways that constitute bike riding. Objectualism presents a third option.O: To know how to ϕ is to stand in a non-propositional, non-behavioral-dispositional objective attitude relation to a way of j-ing. To know how to ride a bike is to have an objectual attitude, perhaps a form of knowledge of, to a way of doing so.Dispositionalism is often dismissed on the basis of two criticisms designed to show its shortcomings relative to Propositionalism and Objectualism. According to the Epistemic Improvement Objection, Dispositionalism cannot account for the fact that gaining knowledge-how is an improvement in our epistemic state. According to the Modified Ability Objection, it cannot account for the fact that being able to do something is neither necessary nor sufficient for knowing how to do it. I develop a form of Dispositionalism, the Special Ability View, that avoids both objections. (shrink)

Demography plays a large role in cultural evolution through its effects on the effective rate of innovation. If we assume that useful inventions are rare, then small isolated societies will have low rates of invention. In small populations, complex technology will tend to be lost as a result of random loss or incomplete transmission (the Tasmanian effect). Large populations have more inventors and are more resistant to loss by chance. If human populations can grow freely, then a population-technology-population positive feedback (...) should occur such that human societies reach a stable growth path on which the rate of growth of technology is limited by the rate of invention. This scenario fits the Holocene to a first approximation, but the late Pleistocene is a great puzzle. Large-brained hominins existed in Africa and west Eurasia for perhaps 50,000 years with, at best, slow rates of technical innovation. The most sophisticated societies of the last glacial period appear after 50,000 years ago and were apparently restricted to west and north-central Eurasia and North Africa. These patterns have no simple, commonly accepted explanation. We argue that increased high-frequency climate change around 70,000–50,000 years ago may have tipped the balance between humans and their competitor-predators, such as lions and wolves, in favor of humans. At the same time, technically sophisticated hunters would tend to overharvest their prey. Perhaps the ephemeral appearance of complex tools and symbolic artifacts in Africa after 00,000 years ago resulted from hunting inventions that allowed human populations to expand temporarily before prey overexploitation led to human population and technology collapse. Sustained human populations of moderate size using distinctively advanced Upper Paleolithic artifacts may have existed in west Eurasia because cold, continental northeastern Eurasia–Beringia acted as a protected reserve for prey populations. (shrink)

Followers’ perceptions of their leaders’ ethics have the potential to impact the way they react to the influence of these leaders. The present study of 365 U.S. Air Force Academy Cadets examined how followers’ perceptions of their leaders’ ethics moderated the relationships found between the leaders’ use of power, as conceptualized by French and Raven, and the followers’ contextual performance. Our results indicated that leaders’ use of expert, referent, and reward power was associated with higher levels of organizational citizenship behaviors (...) among their followers when the followers perceived these leaders to be more ethical. Moreover, when followers perceived their leaders to be less ethical, these followers reported lower levels of OCBs when their leaders’ utilized referent power. Practical implications, limitations, and future research are also discussed. (shrink)

Recently, Richard Healey and Simon Friederich have each advocated a pragmatist interpretation of quantum mechanics as a way to dissolve its foundational problems. The idea is that if we concentrate on the way quantum claims are used, the foundational problems of quantum mechanics cannot be formulated, and so do not require solution. Their central contention is that the content of quantum claims differs from the content of non-quantum claims, in that the former is prescriptive whereas the latter is descriptive. Healey (...) also argues that claims about non-decoherent systems are largely devoid of content. I consider various objections to these claims, noting in particular the ways in which the application of pragmatism to quantum mechanics differs from previous examples of pragmatist therapy. I conclude that a pragmatist dissolution of the foundational difficulties of quantum mechanics is promising, but requires fairly radical changes to our understanding of the content of propositions and the extent of physical explanation. (shrink)

Radical skepticism about the external implies that no belief about the external is even prima facie justified. A theoretical reply to skepticism has four stages. First, show which theories of epistemic justification support skeptical doubts (show which theories, given other reasonable assumptions, entail skepticism). Second, show which theories undermine skeptical doubts (show which theories, given other reasonable assumptions, do not support the skeptic’s conclusion). Third, show which of the latter theories (which non-skeptical theory) is correct, and in so doing show (...) that all of the rival theories of justification, skeptical and non-skeptical alike, are mistaken. Fourth, explain why skeptical doubts are sometimes (or sometimes merely seem) intuitive, and thereby accommodate skeptical doubts without capitulation. Michael Williams has pioneered the very idea of a theoretical reply. A theoretical diagnosis consists in just the first two stages. An adequate reply, which is correct at each stage, would rebut the skeptic entirely. Williams’ own reply, I argue, is inadequate. I offer in its place an exhaustive and accurate diagnosis of skepticism. I distinguish four kinds of skepticism and five theories of justification. I then show which theories do, and which theories do not, support which kinds of skepticism. (shrink)

Know-how has a distinctive, non-instrumental value that a mere reliable ability lacks. Some, including Bengson and Moffett Knowing how, Oxford University Press, Oxford, pp 161–195, 2011) and Carter and Pritchard :799–816, 2015b) have cited a close relation between knowhow and cognitive achievement, and it is tempting to think that the value of know-how rests in that relation. That’s not so, however. The value of know-how lies in its relation to the fundamental value of autonomy.